Steroids and derivatives
Selleck Chemical LLC 5alpha-Cholestan-3-one S5125-25mg
5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | MFCD01074033 | 99.8% | 1 MG
Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Estradiol-d5 | 221093-45-4 | >99.7% | 5 MG
Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound.
Selleck Chemical LLC Estradiol Benzoate S4110-50mg
Estradiol benzoate( -Estradiol 3-benzoate) is an estradiol analog which binds to the human murine and chicken ER with IC50 of 22-28 nM
Apexbio Technology LLC Mifepristone, 100mg. Cas: 84371-65-3 MFCD: MFCD00867226. Progesterone receptor antagonist
Mifepristone (RU486) is a potent antagonist of progesterone receptor, used as a contraceptive agent. 84371-65-3. MFCD00867226
Selleck Chemical LLC Dexamethasone palmitate S5184-25mg
Dexamethasone palmitate (DXP) a lipophilic prodrug of Dexamethasone (DXM) is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity
Cayman Chemical 1-hydroxy VItamIn D2 1mg
A synthetic prodrug of 1,25-dihydroxy vitamin D2; used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; stimulates bone growth; inhibits the growth of certain blastomas and prostate cancer cells
Medchemexpress LLC Cortodoxone-d2 | 1271728-08-5 | 99.0% | C21H28D2O4 | 1 MG
Cortodoxone-d2 is a deuterium labeled glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone). It is suitable for use as a tracer or an internal standard for quantitative analysis in various analytical techniques.
- Can be used as a tracer.
- Acts as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes as tracers for quantitation in drug development.
- Deuteration offers potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Verapamil-d3 hydrochloride | 2714485-49-9 | 99.57% | C27H36D3ClN2O4 | 5 MG
Verapamil-d3 hydrochloride is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride is a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. It also inhibits CYP3A4 and has potential for research into high blood pressure, heart arrhythmias, and angina.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 1α,25-dihydroxy-3-epi-vitamin D3 | 61476-45-7 | MFCD28963706 | 98.5% | 416.64 g/mol | C27H44O3 | 1 MG
(1S)-Calcitriol is the 1S stereoisomer of calcitriol, a biologically active vitamin D metabolite that functions as a vitamin D receptor (VDR) agonist. Supplied as a solid research reagent, it is intended for in vitro studies of vitamin D signaling and nuclear receptor biology. The product includes storage and solubility guidance to maintain compound integrity.
- Acts as a vitamin D receptor (VDR) agonist for mechanistic studies.
- High purity suitable for in vitro assays.
- Recommended solubility in DMSO for stock preparations.
- Stable as a solid when stored protected from light at 4°C.
- Available in small solid pack sizes for research use.
Apexbio Technology LLC Ecdysterone 5289-74-7 20mg
Ecdysterone (CAS 5289-74-7) is a naturally occurring phytoecdysteroid predominantly isolated from Cyanotis arachnoidea It functions as an agonist of the ecdysone receptor modulating gene expression associated with growth protein synthesis and cellular differentiation Ecdysterone has been investigated for its anabolic effects without significant androgenic activity making it a subject of interest in muscle biology and metabolic research Soluble in methanol and DMSO this compound is suitable for a range of in vitro and in vivo studies examining molecular mechanisms underlying cellular growth and adaptation Store Ecdysterone in a cool dry and sealed environment
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | MFCD00064136 | 98.9% | 1493.5 g/mol | 500 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone and acts as a glucocorticoid receptor agonist and apoptosis inducer. It is used in experimental animals to construct models of muscle atrophy, hypertension, and depression. This compound can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes, with potential for COVID-19 research.
- Regulates transcription factors like activator protein-1, nuclear factor-AT, and nuclear factor-kB.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells.
- Used in animal modeling for muscle atrophy, hypertension, and depression.
Apexbio Technology LLC α-Estradiol 57-91-0 50mg
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia